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EC number: 246-562-2
CAS number: 25013-15-4
The body weight of animals increased throughout the study. The exposure
to the test substance had no influence on the body weight of the
animals. The individual values of body weight are presented in Tables 1
During the course of the experiment the animals did not show any
clinical symptoms of intoxication. At the end of experiment the animals
were sacrificed (ether narcosis).
Evaluation of skin reactions
Evaluation of skin reactions after induction
The skin reaction evaluation of the test area of all animals from the
exposed group showed intense erythema around the first and third
injection sites and moderate erythema around the second injection sites.
These changes faded away 96 hours after evaluation. The skin reaction
evaluation of the test area of all animals from the control group showed
intense erythema around the first injection sites and moderate erythema
around the third injection sites. There were no visible changes around
the second injection sites. These changes faded away after 72 hours
The evaluation of skin reactions of the exposed group showed in all
animals discrete erythema in the test area which faded away 24 hours
The evaluation of skin reactions in the control group with olive oil
showed no visible changes in the skin of all animals.
Evaluation of skin reactions after challenge
Exposed group at 48 hours after the challenge
The evaluation of skin reactions in the exposed group carried out 48
hours after the start of the challenge phase of the study showed
discrete erythema in the skin of 1 animal on the left flank where the
test substance was applied (Table 3).
Exposed group at 72 hours after the challenge
The evaluation of skin reactions in the exposed group carried out 72
hours after the start of the challenge phase of study did not show any
changes in the skin of the animals on either flank (Table 3) .
Control group at 48 and 72 hours after the challenge
The evaluation of skin reactions in the control group carried out 48 and
72 hours after the start of the challenge phase of study did not show
any changes in the skin of the animals on either flank (Table 3).
In a dermal sensitization study (16-564) with Vinyltoluene (≥99.2%;
3-methylstyrene (CAS No. 100-80-1): 64.3 % w/w
4-methylstyrene (CAS No. 622-97-9): 35.7 % w/w) in olive oil, young
adult BFA albino guinea pigs were tested using the guinea pig
maximisation test. For induction, 20% vinyltoluene in olive oil
(intradermal injections) and 100% vinyltoluene (topical application) was
used. For challenge, 70% vinyltoluene in olive oil was used for topical
application. The evaluation of skin reactions after challenge was
carried out at 48 and 72 hrs. The positive control was
Vinyltoluene caused a positive skin reaction in 1 of 20 animals, i.e. in
5 % of animals which were exposed to the test substance. There were no
reactions in the control group. The exposed animals showed no other
negative clinical symptoms throughout the experiment. The body weight of
animals increased during the study and it was not affected by the
treatment. In this study, Vinyltoluene is not a dermal sensitizer.
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