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EC number: 246-562-2
CAS number: 25013-15-4
study was conducted to determine the 21 d chronic toxicity of the test
substance to aquatic invertebrates using the EPI SUITE ECOSAR v 1.0 and
1.11 model. The estimated ChV (chronic value) in D. magna was
0.451 mg/L. The ChV corresponds to the geometric mean of the NOEC and
LOEC. Thus, according to ECHA REACH Guidance R.10, the ChV can be
divided by √2 to derive a NOEC. In this case 0.451 mg/L was divided by
root 2 to give a NOEC value of 0.32 mg/L. The same type of model was run
for Mysid saltwater shrimp. The obtained ChV value was 0.098, which
gives a NOEC of 0.07 mg/L. The same values were obtained for the meta-
and para-isomers of the substance. Under the study conditions, the 21 d
NOEC for D. magna and Mysid shrimp were estimated to be 0.32 and
0.07 mg/L, respectively (US EPA, 2017).
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