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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
The substance falls within the applicability domain of the selected (Q)SAR method.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EPI SUITE, ECOSAR v 1.0 and 1.11

Test material

Constituent 1
Chemical structure
Reference substance name:
Vinyltoluene
EC Number:
246-562-2
EC Name:
Vinyltoluene
Cas Number:
25013-15-4
Molecular formula:
C9H10
IUPAC Name:
1-methyl-2-vinylbenzene
Test material form:
liquid

Test organisms

Test organisms (species):
Daphnia magna

Study design

Total exposure duration:
21 d
Remarks on exposure duration:
Chronic QSAR

Results and discussion

Effect concentrationsopen allclose all
Key result
Duration:
21 d
Dose descriptor:
other: ChV
Effect conc.:
0.451 mg/L
Nominal / measured:
not specified
Conc. based on:
act. ingr.
Basis for effect:
other: QSAR (D. magna)
Key result
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.32 mg/L
Nominal / measured:
not specified
Conc. based on:
act. ingr.
Basis for effect:
other: QSAR (D. magna)
Key result
Duration:
21 d
Dose descriptor:
other: ChV
Effect conc.:
0.098 mg/L
Nominal / measured:
not specified
Conc. based on:
act. ingr.
Basis for effect:
other: QSAR (Mysid shrimp)
Key result
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.07 mg/L
Nominal / measured:
not specified
Conc. based on:
act. ingr.
Basis for effect:
other: QSAR (Mysid shrimp)
Details on results:
The estimated toxicity to D magna using the EPA ECOSAR model is 0.451 mg/L (ChV). According to ECHA Guidance on information requirements and chemical safety assessment Chapter R.10, if in the test report only the ChV is presented, the ChV can be divided by √2 to derive a NOEC. 0.451 mg/L was divided by root 2 to give a NOEC value of 0.32 mg/L. The same type of model was run for Mysid salt water shrimp. Obtained by modelling ChV value was 0.098, which gives the NOEC of 0.07 mg/L.

Applicant's summary and conclusion

Validity criteria fulfilled:
not applicable
Conclusions:
Under the study conditions, the 21 d NOEC for D. magna and Mysid shrimp were estimated to be 0.32 and 0.07 mg/L, respectively.
Executive summary:

A study was conducted to determine the 21 d chronic toxicity of the test substance to aquatic invertebrates using the EPI SUITE ECOSAR v 1.0 and 1.11 model. The estimated ChV (chronic value) in D. magna was 0.451 mg/L. The ChV corresponds to the geometric mean of the NOEC and LOEC. Thus, according to ECHA REACH Guidance R.10, the ChV can be divided by √2 to derive a NOEC. In this case 0.451 mg/L was divided by root 2 to give a NOEC value of 0.32 mg/L. The same type of model was run for Mysid saltwater shrimp. The obtained ChV value was 0.098, which gives a NOEC of 0.07 mg/L. The same values were obtained for the meta- and para-isomers of the substance. Under the study conditions, the 21 d NOEC for D. magna and Mysid shrimp were estimated to be 0.32 and 0.07 mg/L, respectively (US EPA, 2017).