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EC number: 246-562-2
CAS number: 25013-15-4
A study was conducted to determine the
toxicity of the test substance when applied to the skin of albino
rabbits during a period of 21 consecutive days. The test substance was
applied dermally to groups of 3 male and 3 female New Zealand rabbits,
daily, at dose volumes of 0.5 or 2.0 mL/kg bw/day. Controls received 2.0
mL/kg bw/day of distilled water. The test substance was in contact with
the skin, non-occluded, for 6 h each day. Clinical signs were recorded
daily and body weight weekly. Blood samples for haematology and clinical
chemistry were taken prior to treatment and at termination. All rabbits
were subject to necropsy and limited histopathology. Under the study
conditions, there were no results to suggest systemic toxicity. However,
the test substance caused moderate to severe skin irritation. Further,
the irritation resulted in pain, reduced body weight, elevated white
blood cells and increase in segmented and non-segmented neutrophils. By
Day 9, the surface layer of skin sloughed or peeled off and the
underlying skin was golden to black colour. The severity of skin
response was similar in both test groups. The only effect on the
clinical chemistry parameters was an elevation in the serum glutamic
oxaloacetic transaminase (SGOT) enzyme which was probably related to the
skin cell damage at the application site. The renal collecting tubules
of some of the rabbits were more visible than normally observed and they
were white and the renal medulla was brownish – pink (pale) colour
rather than a normal red colour. No NOAEL was established for the study
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