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EC number: 263-058-8
CAS number: 61789-40-0
A repeated dose toxicity study was
performed in rats to determine the toxic nature of the test chemical.
Ten male and 10 female rats were used during the 28 days study. The test
substance was administered in olive oil, at doses of 750, 250 and 70
mg/kg body weight per day for 14 days. After 14 days the dose in the 750
mg/kg body weight test group was increased to 1500 mg/kg body weight per
day. Recovery groups consisting of five males and five females per dose
level were used to determine the reversibility of possible compound
related findings. The compatibility of the test substance was evaluated
after 28 days of treatment. None of the rats died. Body weight gain and
total increase in body weight did not differ from control values and no
significant compound-related gross pathology or tissue damage was noted.
Biochemical parameters did not show any signs of irregulations. Slight
alterations of phosphate in the highest group were noted and regarded as
dose /compound -related but not as a critical effect. Gonads were
examined histologically. At the highest feasible dose, 750 mg/kg, daily
for 28 days, no lethal dose was attained indicating that the test
chemical is not toxic in nature.
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