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EC number: 263-058-8
CAS number: 61789-40-0
An acute dermal toxicity study was
performed on rabbits to determine the toxic nature of the test chemical.
Three male and three female Albino Rabbits weighing 1.9 -2.7 kg were
dosed at a single concentration of 2000 mg/kg bw. Prior to dosing the
trunk of each animal was clipped free of hair. Three of the animals (two
male, one female) were further prepared by introducing epidermal
abrasions over the clipped skin surface to enhance penetrability of the
test substance through the stratum corneum. After test substance
application the trunk of each animal was encased in a sleeve of
plasticized material for 24 hours. Following the 24-hour exposure period
the sleeve was removed and the skin sites gently cleansed. All animals
were observed daily thereafter for 14 days for mortality, skin response
and general behavior. No mortality was observed, and all animals
appeared normal during the 14 days observation period. Two females that
had abraded skin lost weight (0.01 and 0.25 kg) over the 14-day
post-exposure period. All remaining rabbits gained weight through day
14. Thus, the LD50 was observed to be >2000 mg/kg bw indicating that the
test chemical is not toxic in nature and falls under category 'Not
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