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EC number: 263-058-8
CAS number: 61789-40-0
Acute oral toxicity study was
conducted according to OECD guideline 401 by using test chemical in 10
male and female CD rats at the dose concentration of 5000 mg/kg bw. The
given test chemical (31% active ingredient) was administered via oral
route.Animals were observed immediately after dosing and at frequent
intervals for the remainder of Day 1. On subsequent days, the animals
were observed once in the morning and again at the end of the
experimental day. Clinical signs were recorded at each observation.
Individual body weights were recorded on days 1, 8 and 15. Necropsy of
survivors was performed. All animals were killed on Day 15 by cervical
dislocation and were subjected to a macroscopic post mortem examination,
which consisted of opening the abdominal and thoracic cavities. The
macroscopic appearance of abnormal organs, when present, was recorded.No
mortality was observed at 5000 mg/kg bw. Signs of reaction to treatment
observed in all rats shortly after dosing were: piloerection and
increased salivation. Piloerection persisted throughout Day 1 and was
accompanied on Day 2 by abnormal body carriage (hunched posture) and
diarrhea. Recovery, as judged by external appearance and behavior, was
advanced by Day 3 (piloerection alone) and complete by Day 4. Slightly
low body weight gains were recorded for 4 males and 3 females on Day 8.
All rats achieved anticipated body weight gains during the second week
of the study. Terminal autopsy findings were normal. Therefore, LD50
value was considered to be >5000 mg/kg (>1500 mg/kg active ingredient),
when 10 male and female CD rats were treated with test chemical via oral
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