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EC number: 203-445-0
CAS number: 106-94-5
This developmental toxicity study, conducted for the Brominated Solvents
Consortium (BSOC), was designed to assess the potential maternal and/or
embryo-fetal toxicity of inhaled 1-Bromopropane in the pregnant rat.
Seventy-five pregnant rats (25 per group) were exposed for six hours
daily from Gestation Day (GD) 6 through the period of organogenesis (GD
19) at levels of 0.5, 2.5, and 5.0 mg/L (100, 498, and 996 ppm,
respectively). The control group was comprised of twenty-five pregnant
rats that received the filtered air, using the same exposure regimen as
the treated animals. A cesarean section was performed on all rats on GD
20. The experiment was performed according to OECD 414 and EPA OPPTS
870.3600 and to GLP standard.
No adverse effects of 1-Bromopropane exposure on mortality, or
macroscopic postmortem evaluations on day 20 of gestation were observed.
The 996 ppm 1-Bromopropane exposure group exhibited a higher incidence
of red stains on the snout or head, bilateral or unilateral lacrimation,
and excessive salivation immediately post-exposure. Exposure-related
decreases in maternal body weight, body weight gain and feed consumption
were observed in rats exposed to 498 and 996 ppm of 1-Bromopropane. No
effect of 1-Bromopropane exposure at 100, 498 or 996 ppm on pregnancy
rates, implantation data, sex distribution or fetal external, skeletal
or visceral malformations were observed. There was a significant and
dose related increase in the litter incidence of reduced ossification of
the fetus in the 498 ppm and 996 ppm exposure groups. This reduction in
fetal ossification is probably associated with maternal toxicity and
reduced fetal body weights in these two groups. There was a significant
increase in the 996 ppm exposure group in the litter incidence of bent
rib(s) and a slight, but not statistically significant, increase in the
litter incidence of hyoid body/arch(es) unossified, sternebra(e) 5
and/or 6 unossified and reduced ossification of ribs. The bent ribs are
considered 1-Bromopropane exposure-related; however, the literature
supports that this condition is reversible and not uncommonly observed
in untreated control rats (Nishimura et al., 1982; Kast, 1994).
The results of this developmental toxicity study revealed no maternal or
fetal toxicity at 100 ppm exposure level. Slight maternal toxicity and
slight fetal toxicity were observed in the 498 ppm group. Moderate to
severe maternal toxicity and slight to moderate fetal toxicity was
observed in the 996-ppm exposure group. Therefore, the
No-Observable-Effect-Level (NOEL) for maternal toxicity and fetal
toxicity is 100 ppm and for teratogenicity is 996 ppm.
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