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EC number: 203-445-0
CAS number: 106-94-5
An acute dermal irritation study was performed on 1-bromopropane using albino rabbits (24 hour exposure, tests sites both intact and abraded) representing a worst case scenario for assessing irritation.Edema was observed in one out of the six animals tested. No eschar formation was observed. 1-bromopropane is considered as a non-irritant. However signs of ulceration and necrosis were seen in all dose levels of the available acute dermal toxicity test (Paster (1979)).An acute eye irritation study was performed on 6 male rabbits. Grading of eye irritation was according to the scale of Draize and the Illustrated Guide for Grading Eye Irritation published by the F.D.A. Scoring method was that of the Consumer Product Safety Commission, Federal Register vol. 38, No. 187, 1500.42. Since two out of the six animals tested exhibited a positive reaction, the test was repeated using a group of six different rabbits. The second test was considered positive since three animals out of six tested exhibited positive reactions. 1-bromopropane is considered an eye irritant.Acute respiratory irritation was observed during the Schorsch (1997) study (see section 7.2, Acute toxicity: inhalation.001) and was found to cause mortalities at concentrations above 30200 mg/m³.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: irritating
Effects on respiratory irritation: irritating
According to section 220.127.116.11 of Directive 67/548/EEC, the substance does
not meet the quantitative criteria for classification as irritating to
the skin (R38). However, section 18.104.22.168 also states relevant data may
also be available from non-acute animal studies, which should be
considered significant if the effects seen are comparable to the
quantitative criteria. A high dose dermal toxicity study on n-propyl
bromide in rabbits by Paster (1979) indicates skin ulceration and
necrosis at all doses (range 2.5 – 10 mL/kg, approximately 3375 – 13,500
mg/kg). Although both the skin irritation study and the dermal toxicity
study both used 24 hour exposure times, it should be noted that the dose
volumes used for the dermal toxicity study were substantially higher
than for a standard dermal irritation study, which may account for the
differences in irritation responses seen between the two studies.
However, given the effects seen in the dermal toxicity study, n-propyl
bromide may require classification as a skin irritant (R38).
The eye irritation study data available indicates that n-propyl bromide
is an eye irritant, and as such the substance requires classification
Substances which cause serious irritation of the respiratory system
based on either practical observation in humans or positive results from
appropriate animal tests should be classified as irritating to the
respiratory system (R37). An acute inhalation study on n-propyl bromide
by Schorsch (1997) dosed rats at 30 to 42 g/m3 and reported inflammation
and oedema in the lungs. n-propyl bromide therefore requires
classification as a respiratory system irritant.
Taking the above into account, n-propyl bromide is officially classified
as Xi, R36/37/38 on Annex I of Directive 67/548/EEC and as a Skin
Irritant Category 2, and Eye Irritant Category 2 and a STOT SE Category
3 on Annex VI of the EU Classification, Labelling and Packaging of
Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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