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EC number: 203-445-0
CAS number: 106-94-5
The genotoxic potential of n-propyl bromide was assessed by the Ames
test on five Salmonella typhimurium tester strains: TA1353,
TA1537, TA1538, TA98 and TA100, both in the absence and presence of
n-propyl bromide was dissolved and diluted in dimethyl sulfoxide and
tested at concentrations ranging from 100 to 10,000 µg/plate.
During the first genotoxicity study (HIS1005) performed at 100, 500,
1000, 5000 and 10,000 µg/plate, a slight toxic effect was observed
mainly at 10,000 µg/plate on the five tester strains with S9 mux and in
TA1535, TA 1538, TA98 and TA100 without S9 mix.
A second study (HIS1005A) performed at the same concentrations confirmed
In both studies, whether in the presence or in the absence of metabolic
activation, no increase was observed in the number of His+ revertant
colonies/plate at any of the concentrations tested, on the five tester
strains, with and without S9 mix.
In conclusion, n-propyl bromide was not genotoxic in the Ames test, with
or without metabolic activation.
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