Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 203-445-0 | CAS number: 106-94-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Three studies are available for the acute oral toxicity endpoint:
Clauzeau. J (1993) - LD50 (rat): >2000 mg/kg bw
Paster. Z (1978a) - LD50 (rat): 4260 mg/kg bw
Paster. Z (1978b) - LD50 (rabbit): 540 mg/kg bw
Three studies are available for the acute inhalation toxicity endpoint:
Schorsch. F (1997) - 4h-LC50 (rat): 35000 mg/m^3
Moon. Y.H. et al (1998) - 4h-LC50 (rat): 14374 ppm
Labbé. R (1997a) - 6h-LC50 (rat): between 25 and 35 mg/L
Two studies are available for the acute dermal toxicity endpoint:
de Jouffrey. S (1995a) - LD50 (rat): >2000 mg/kg bw
Paster. Z (1979) - LD50 (rabbit): >10 mL/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 35 000 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Key values have been selected from suitable available studies (i.e. use of recognised species for a given endpoint, recognised exposure time), together with a worst case approach.
Key studies for inhalation have been selected for both systemic toxicity and local effects. The systemic toxicity via inhalation value is taken from the Moon et al (1998) study in which effects seen at the lowest treatment group (10909ppm) consisted of slow reactions and ataxia observed in some animals. These results were considered to represent a NOAEC value as no mortality or other signs of systemic toxicity were observed at this concentration.
The local effects via inhalation NOAEC value is taken from the Schorsch (1997) study in which inflammation of the lung parenchyma which was characterised by pulmonary emphysema and oedema was observed in all test groups, and caused mortalities in test groups above 30.2g/m3. The lowest test group (30.2g/m3) was therefore identified as the NOAEC concentration as local effects did not cause mortalities.
Justification for classification or non-classification
Based upon the high LD50 and LC50 values for oral, dermal and inhalation exposure, and the absence of other major significant effects, the test substance does not need to be classified for acute toxicity according to Directive 67/548/EEC or Regulation (EC) No 1272/2008.
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