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EC number: 203-445-0
CAS number: 106-94-5
Three studies are available for the acute oral toxicity endpoint:Clauzeau. J (1993) - LD50 (rat): >2000 mg/kg bwPaster. Z (1978a) - LD50 (rat): 4260 mg/kg bwPaster. Z (1978b) - LD50 (rabbit): 540 mg/kg bwThree studies are available for the acute inhalation toxicity endpoint:Schorsch. F (1997) - 4h-LC50 (rat): 35000 mg/m^3Moon. Y.H. et al (1998) - 4h-LC50 (rat): 14374 ppmLabbé. R (1997a) - 6h-LC50 (rat): between 25 and 35 mg/LTwo studies are available for the acute dermal toxicity endpoint:de Jouffrey. S (1995a) - LD50 (rat): >2000 mg/kg bwPaster. Z (1979) - LD50 (rabbit): >10 mL/kg bw
Key values have been selected from suitable available studies (i.e. use
of recognised species for a given endpoint, recognised exposure time),
together with a worst case approach.
Key studies for inhalation have been selected for both systemic toxicity
and local effects. The systemic toxicity via inhalation value is taken
from the Moon et al (1998) study in which effects seen at the lowest
treatment group (10909ppm) consisted of slow reactions and ataxia
observed in some animals. These results were considered to represent a
NOAEC value as no mortality or other signs of systemic toxicity were
observed at this concentration.
The local effects via inhalation NOAEC value is taken from the Schorsch
(1997) study in which inflammation of the lung parenchyma which was
characterised by pulmonary emphysema and oedema was observed in all test
groups, and caused mortalities in test groups above 30.2g/m3.
The lowest test group (30.2g/m3) was therefore identified as
the NOAEC concentration as local effects did not cause mortalities.
Based upon the high LD50 and LC50 values for oral, dermal and inhalation
exposure, and the absence of other major significant effects, the test
substance does not need to be classified for acute toxicity according to
Directive 67/548/EEC or Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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