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EC number: 203-445-0
CAS number: 106-94-5
All rats survived to the end of the study. The final mean body weight
and mean body weight gain of 1,000 ppm males were significantly less
than those of the chamber controls. Mean body weights of exposed females
were similar to those of the chamber controls.
There were no changes in hematology endpoints that were considered
related 1-bromopropane exposure. There were early, transient decreases
in albumin and total protein concentrations and alanine aminotransferase
activities in most exposed groups of male and female rats. These
transient decreases may have been associated with effects of
1-bromopropane on hepatic protein metabolism. Additionally, sorbitol
dehydrogenase (SDH) activity was increased at day 23 and at the end of
the study in females exposed to 1,000 ppm and at the end of the study in
males exposed to 500 or 1,000 ppm. Increased SDH activity would be
consistent with mild hepatotoxicity caused by 1-bromopropane.
The absolute and relative liver weights of males exposed to 250 ppm or
greater and females exposed to 125 ppm or greater were significantly
increased. The absolute spleen weights of females exposed to 125 ppm or
greater and the relative spleen weight of 1,000 ppm females were greater
than those of the chamber controls. In addition, the absolute and
relative right kidney weights of 1,000 ppm females were greater than
those of the chamber controls.
There were significant exposure concentration-related decreases in sperm
motility in male rats exposed to 250 ppm or greater (6.7%, 10.1%, and
27.7% in the 250, 500, and 1,000 ppm groups, respectively), and there
were significant decreases in the number of sperm per gram cauda and the
total sperm per cauda (25.2% and 36.8%, respectively), as well as
significant decreases in the absolute weights of the cauda (14%) and
left epididymis (19%) of 1,000 ppm male rats. Female rats in each of the
exposure groups evaluated differed significantly from the chamber
controls in the relative amount of time spent in the various estrous
cycle stages, with each exposed group spending significantly more time
in extended estrus and significantly less time in extended diestrus.
Treatment-related lesions occurred in the liver. There were
significantly increased incidences of hepatocellular cytoplasmic
vacuolization in males exposed to 250 ppm or greater and in females
exposed to 500 or 1,000 ppm. The incidence of hepatocellular vacuolar
degeneration was significantly increased in 1,000 ppm females.
Hepatocellular cytoplasmic vacuolization consisted of swollen
hepatocytes with centrally located nuclei and one to three variably
sized vacuoles displacing the cytoplasm. Hepatocellular vacuolar
degeneration consisted of a distinct population of enlarged,
pale-staining, degenerative, “balloon-like” cells admixed with low
numbers of necrotic hepatocytes. The lesion involved hepatocytes
surrounding the central vein, but in the most severe cases, the
vacuolated hepatocytes extended into the midzonal region.
The incidence of minimal, suppurative, prostatic inflammation in 1,000
ppm males was increased, but the increase was not statistically
significant. The increasing trend of this lesion, however, was
significant. Because this lesion is a common background finding in
F344/N rats, the biological significance of the increased incidence in
the 1,000 ppm males is unclear.
Groups of 10 male and 10 female rats were exposed to 1-bromopropane
vapor at concentrations of 0, 62.5, 125, 250, 500, or 1,000 ppm, 6 hours
plus T90 (10 minutes) per day, 5 days per week for 14 weeks. Additional
clinical pathology groups of 10 male and 10 female rats were exposed to
the same concentrations for 23 days. All rats survived to the end of the
study. Mean body weights of 1,000 ppm males were significantly less than
those of the chamber controls. The increases in sorbitol dehydrogenase
activities in 500 ppm males and 1,000 ppm males and females were
consistent with the histopathologic evidence of mild hepatotoxicity
caused by 1-bromopropane. Liver weights of males exposed to 250 ppm or
greater and of females exposed to 125 ppm or greater were significantly
increased. Spleen and kidney weights of 1,000 ppm females were
significantly increased. Results of sperm count and vaginal cytology
evaluations showed exposure concentration-related decreases in sperm
motility and counts in male rats, reaching 28% and 37%, respectively, in
the 1,000 ppm group. Female rats in all three exposure groups evaluated
exhibited altered estrous cycles, spending significantly more time in
extended estrus and less time in extended diestrus. The incidences of
cytoplasmic vacuolization of the liver were significantly increased in
males exposed to 250 ppm or greater and in females exposed to 500 ppm or
greater. Hepatocyte degeneration was also observed in 1,000 ppm females.
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