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EC number: 203-445-0
CAS number: 106-94-5
Very slight to well defined erythema was observed in 40% of the animals
after 24 hours and 30 % after 48 hours of the removal of the dressing.
Dryness of the skin was oberved in 3/10 animals at the 48 hour reading.
No oedema was observed 24 and 48 hours after removal of the dressing of
the challenge cutaneous application of the test substance.
Skin of the treated right flank (100 % concentration test substance) was
examined in 4/10 females showing cutaneous reactions.
Slight to moderate acanthosis, sometimes together with minimal
hyperkeratosis was noted in all 4 females. This was associated with
minimal mononuclear cell and minimal to slight granulocyte inflamation
if the upper dermis in all 4 females; extravasation of red blood cells
was noted in the upper dermis of 1/4 examined females.
No treated skin from the 4/10 examined females showed spongiosis and in
the absence of the classical association of spongiosis, acanthosis and
mononuclear cell infiltration of dermis, the above mentioned lesions
reported in 4/10 examined females were equivocal.
Acanthosis can be seen in cases of irritative inflammatory reaction and
the minimal microscopic changes noted in the 4/10 examined females might
be related to application of the test substance at 100 % concentration
A skin sensitization study according to the maximisation method of
Magnusson and Kligman was performed on female Dunkin-Hartley guinea-pigs
weighing 343 ± 22 g. The study was performed using the test substance
1-bromopropane and in accordance with OECD 406 and to GLP standard.
No cutaneous reactions possibly attributable to the sensitization
potential of the test substance were observed and the material is
therefore not classed as a sensitizer.
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