Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Bioaccumulation: aquatic / sediment

The bioaccumulation study was conducted for estimating the BCF (bioaccumulation factor) value of test chemical (HSDB and PubChem, 2017). The bioaccumulation factor (BCF) value was calculated using a logKow of 1.26 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 3.6 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-accumulative in aquatic organisms.

Additional information

Bioaccumulation: aquatic / sediment

Various experimental studies and predicted data of the test chemical and supporting studies for its structurally similar read across substance were reviewed for the bioaccumulation end point which are summarized as below:

 

In an experimental key study from authoritative database (HSDB and PubChem, 2017) for the test chemical,the bioaccumulation study was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a logKow of 1.26 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 3.6 dimensionless.

 

In a prediction done using the BCFBAF Program (v3.01) of Estimation Programs Interface (EPI Suite, 2018) was used to predict the bioconcentration factor (BCF) of test chemical. The bioconcentration factor (BCF) of test chemical was estimated to be 3.15 L/kg whole body w.w (at 25 deg C).

 

In an another prediction done by using Bio-concentration Factor module (ACD (Advanced Chemistry Development)/I-Lab predictive module, 2017)), Bio-concentration Factor of the test chemical was estimated to be 1, 1.05, 3.65, 4.85, 4.95, 4.35, 1.95 and 1 at pH range 0-1, 2, 3, 4, 5, 6, 7 and 8-14, respectively.

 

Another bioaccumulation test was conducted for 8 weeks for determination the bioconcentration factor (BCF) of test chemical on test organism Cyprinus carpio (J-CHECK and HSDB, 2018). Nominal concentrations used in the study are 1st Concentration area: 1 mg/L, 2nd Concentration area: 0.1 mg/L and Range finding study was carried out on Rice fish (Oryzias latipes) TLm(48h) 100 ppm(w/v). Thus the bioconcentration factor (BCF) for test chemical was determined according to static fish test. The BCF value was observed to be 4 L/kg at dose concentration 1 mg/L and 40 L/kg at dose concentration 0.1 mg/L on test organism Cyprinus carpio during 6 weeks period.

 

For the test chemical, the bioaccumulation study was conducted for estimating the BCF (bioaccumulation factor) value of test chemical (authoritative database, 2017). The bioaccumulation factor (BCF) value was calculated using a logKow of 0.88 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 3 dimensionless.

 

On the basis of above overall results for test chemical, it can be concluded that the BCF value of test chemical was evaluated to be ranges from 1 to 5, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.