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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database.

Data source

Reference
Reference Type:
other: authoritative database
Title:
Acute inhalation toxicity of test chemical
Author:
IFA GESTIS
Year:
2018
Bibliographic source:
IFA GESTIS

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute inhalation toxicity study of the given test chemical in rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- IUPAC Name: 2-amino-4-nitrophenol
- InChI: 1S/C6H6N2O3/c7-5-3-4(8(10)11)1-2-6(5)9/h1-3,9H,7H2
- Smiles: Nc1cc(ccc1O)[N+](=O)[O-]
- Molecular formula :C6H6N2O3
- Molecular weight :154.1244 g/mol
- Substance type:organic
- Physical state:Solid, powder yellow

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Remark on MMAD/GSD:
not specified
Details on inhalation exposure:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
527 mg/L (527000 mg/m3)
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
- Other examinations performed: Animals were observed for mortality and clinical signs.
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
527 000 mg/m³ air
Based on:
test mat.
Exp. duration:
4 h
Mortality:
50% mortality was observed at 527 mg/L in treated animals.
Clinical signs:
Data on the symptoms triggered by the substance inhalation are lacking. The substance must be assumed to trigger irritations of the respiratory tract.
After massive exposures, systemic effects must at least be considered to occur.
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The acute inhalation toxicity dose (LC50) was considered to be 527 mg/L (527000 mg/m3), when rats were exposed to the given test chemical via inhalation route for 4 hour exposure.
Executive summary:

The acute inhalation toxicity study was conducted by using the given test chemical in rats at the concentration of 527 mg/L (527000 mg/m3).

Animals were observed for mortality and clinical signs. 50% mortality was observed at 527 mg/L in treated animals. Data on the symptoms triggered by the substance inhalation are lacking. The substance must be assumed to trigger irritations of the respiratory tract. After massive exposures, systemic effects must at least be considered to occur.

Hence, the LC50 value was considered to be 527 mg/L (527000 mg/m3), when rats were exposed to the given test chemical via inhalation route for 4 hour exposure.