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Ecotoxicological information

Toxicity to microorganisms

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Link to relevant study record(s)

Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
for read across substance
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two toxicity study of microorganism for the test chemical :
1) The toxicity of test material was evaluated for test material
2)The effect of test material evaluated for microorganisms
Test organisms (species):
other: 1.Pseudomonas putida 2. Photobacterium phosphoreum
Test type:
static
Water media type:
not specified
Limit test:
no
Total exposure duration:
16 h
Reference substance (positive control):
not specified
Duration:
16 h
Dose descriptor:
EC0
Effect conc.:
7 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Duration:
30 min
Dose descriptor:
EC50
Effect conc.:
29 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
other: bioiluminance
Validity criteria fulfilled:
not specified
Conclusions:
The test chemical is likely to be toxic to microorganism atleast in the concentration range of 7 - 29 mg/l
Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

Acute toxicity of test material was evaluated for microorganisms, the test material showed no effect on Pseudomonas putida when tested for 16 h at concentration 7 mg/l.

In another study , the effect of test material was evaluated on microorganism Photobacterium phosphoreum for 30 min inhibition of bioluminance test  the EC50 was obseved to be 29 mg/l. The test chemical  is  likely to be toxic to microorganism atleast in the concentration  range of 7 - 29 mg/l

Description of key information

Toxicity to microorganism:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

Acute toxicity of test material was evaluated for microorganisms, the test material showed no effect on Pseudomonas putida when tested for 16 h at concentration 7 mg/l.

In another study , the effect of test material was evaluated on microorganism Photobacterium phosphoreum for 30 min inhibition of bioluminance test  the EC50 was obseved to be 29 mg/l. The test chemical  is  likely to be toxic to microorganism atleast in the concentration  range of 7 - 29 mg/l

Key value for chemical safety assessment

EC50 for microorganisms:
29 mg/L

Additional information

Toxicity to microorganism:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

Acute toxicity of test material was evaluated for microorganisms, the test material showed no effect on Pseudomonas putida when tested for 16 h at concentration 7 mg/l.

In another study , the effect of test material was evaluated on microorganism Photobacterium phosphoreum for 30 min inhibition of bioluminance test  the EC50 was obseved to be 29 mg/l. The test chemical  is  likely to be toxic to microorganism atleast in the concentration  range of 7 - 29 mg/l