Registration Dossier
Registration Dossier
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EC number: 202-767-9 | CAS number: 99-57-0
Endpoint summary
Administrative data
Description of key information
Hydrolysis
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 1 yr, at pH range 4, 7 & 9 and a temperature of 25°C or 50°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.
Additional information
Hydrolysis
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:
The half-life of the test chemical was determined at different pH range. The study was performed at a temperature of 25°C and pH of 4, 7 and 9, respectively. As the test chemical has no groups that are susceptible to hydrolysis in the pH range 4 to 9, therefore, it is considered stable to hydrolysis in both surface and groundwater, respectively. The half-life value of test chemical was determined to be > 1 yrat pH 4, 7 and 9, respectively at a temperature of25⁰C. Thus based on this, test chemical is considered to be not hydrolysable.
In an another study, the half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. As the hydrolysis of test chemical did not reach > 10% in any of the pH systems, the preliminary study was terminated. Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of 50⁰C for 5 days. Based on this, it is concluded that the test substance is not hydrolysable.
For the test chemical, the half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 25°C. Although half-life value of test chemical was not known, but chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively & at a temperature of 25⁰C. Thus based on this, test chemical is considered to be not hydrolysable.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 1 yr, at pH range 4, 7 & 9 and a temperature of 25°C or 50°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.
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