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EC number: 202-767-9 | CAS number: 99-57-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute dermal toxicity of test chemical
- Author:
- IFA GESTIS
- Year:
- 2 018
- Bibliographic source:
- IFA GESTIS, GESTIS Substance Database, 2018.
- Reference Type:
- secondary source
- Title:
- HUMAN HEALTH TIER II ASSESSMENT
- Author:
- NICNAS
- Year:
- 2 018
- Bibliographic source:
- INVENTORY MULTITIERED ASSESSMENT AND PRIORITISATION (IMAP) NICNAS
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity study of the given test chemical in rabbit.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2-amino-4-nitrophenol
- EC Number:
- 202-767-9
- EC Name:
- 2-amino-4-nitrophenol
- Cas Number:
- 99-57-0
- Molecular formula:
- C6H6N2O3
- IUPAC Name:
- 2-amino-4-nitrophenol
- Details on test material:
- - IUPAC Name: 2-amino-4-nitrophenol
- InChI: 1S/C6H6N2O3/c7-5-3-4(8(10)11)1-2-6(5)9/h1-3,9H,7H2
- Smiles: Nc1cc(ccc1O)[N+](=O)[O-]
- Molecular formula :C6H6N2O3
- Molecular weight:154.1244 g/mol
- Substance type:organic
- Physical state:Solid, powder yellow
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Type of coverage:
- other: Dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- not specified
- Duration of exposure:
- not specified
- Doses:
- 2190 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 190 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 50% mortality was observed at 2190 mg/kg bw in treated animals.
- Clinical signs:
- not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute dermal LD50 value was considered to be 2190 mg/kg bw, when rabbits were treated with the given test chemical by dermal route.
- Executive summary:
Acute dermal toxicity study of the given test chemical was conducted in rabbits at the dose concentration of 2190 mg/kg bw.
The animals were observed for mortality. 50% mortality was observed at 2190 mg/kg bw in treated animals.
Hence, the LD50 value was considered to be 2190 mg/kg bw, when rabbits were treated with the given test chemical by dermal route.
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