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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Acute dermal toxicity of test chemical
Author:
IFA GESTIS
Year:
2018
Bibliographic source:
IFA GESTIS, GESTIS Substance Database, 2018.
Reference Type:
secondary source
Title:
HUMAN HEALTH TIER II ASSESSMENT
Author:
NICNAS
Year:
2018
Bibliographic source:
INVENTORY MULTITIERED ASSESSMENT AND PRIORITISATION (IMAP) NICNAS

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute dermal toxicity study of the given test chemical in rabbit.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- IUPAC Name: 2-amino-4-nitrophenol
- InChI: 1S/C6H6N2O3/c7-5-3-4(8(10)11)1-2-6(5)9/h1-3,9H,7H2
- Smiles: Nc1cc(ccc1O)[N+](=O)[O-]
- Molecular formula :C6H6N2O3
- Molecular weight:154.1244 g/mol
- Substance type:organic
- Physical state:Solid, powder yellow

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
2190 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 190 mg/kg bw
Based on:
test mat.
Mortality:
50% mortality was observed at 2190 mg/kg bw in treated animals.
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The acute dermal LD50 value was considered to be 2190 mg/kg bw, when rabbits were treated with the given test chemical by dermal route.
Executive summary:

Acute dermal toxicity study of the given test chemical was conducted in rabbits at the dose concentration of 2190 mg/kg bw.

The animals were observed for mortality. 50% mortality was observed at 2190 mg/kg bw in treated animals.

Hence, the LD50 value was considered to be 2190 mg/kg bw, when rabbits were treated with the given test chemical by dermal route.