2-amino-4-nitrophenol

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

experimental data of read across substances

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two hydrolysis studies as-
2., 3. and 4.

GLP compliance:

not specified

Radiolabelling:

not specified

Analytical monitoring:

not specified

Temp.:

25 °C

Remarks:

2. The study was performed at pH 4, 7 and 9, respectively.

Duration:

5 d

Temp.:

50 °C

Remarks:

3. Study was performed at different pH range, i.e., at pH 4, 7 and 9, respectively.

Temp.:

25 °C

Remarks:

4. The study was performed at pH 4, 7 and 9, respectively.

Positive controls:

not specified

Negative controls:

not specified

Transformation products:

not specified

Temp.:

25 °C

DT50:

> 1 yr

Remarks on result:

other: 2. The study was performed at pH 4, 7 and 9, respectively. No hydrolysis was noted at any of the three levels of pH tested.

Temp.:

50 °C

Remarks on result:

other: 3. Hydrolysis half-life value of test chemical was not known, but hydrolysis of test chemical did not reach > 10% in any of the pH systems (i.e., at pH 4, 7 and 9, respectively) and thus the preliminary study was terminated.

Temp.:

25 °C

Remarks on result:

other: 4. Hydrolysis half-life value of test chemical was not known, but test chemical was reported to be stable at all the three pH levels (i.e, at pH 4, 7 and 9).

Details on results:

2. The half-life value of test chemical was determined to be > 1 yr at pH 4, 7 and 9, respectively at a temperature of 25⁰C. As the test chemical has no groups that are susceptible to hydrolysis in the pH range 4 to 9, therefore, it is considered stable to hydrolysis in surface and groundwater, respectively.

3. Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of 50⁰C for 5 days.

4. Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of 25⁰C.

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 1 yr, at pH range 4, 7 & 9 and a temperature of 25°C or 50°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.

Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical.The studies are as mentioned below:

The half-life of the test chemical was determined at different pH range. The study was performed at a temperature of 25°C and pH of 4, 7 and 9, respectively. As the test chemical has no groups that are susceptible to hydrolysis in the pH range 4 to 9, therefore, it is considered stable to hydrolysis in both surface and groundwater, respectively. The half-life value of test chemical was determined to be > 1 yrat pH 4, 7 and 9, respectively at a temperature of25⁰C. Thus based on this, test chemical is considered to be not hydrolysable.

In an another study, the half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. As the hydrolysis of test chemical did not reach > 10% in any of the pH systems, the preliminary study was terminated. Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of 50⁰C for 5 days. Based on this, it is concluded that the test substance is not hydrolysable.

For the test chemical, the half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 25°C. Although half-life value of test chemical was not known, but chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively & at a temperature of 25⁰C. Thus based on this, test chemical is considered to be not hydrolysable.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 1 yr, at pH range 4, 7 & 9 and a temperature of 25°C or 50°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.

Description of key information

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 1 yr, at pH range 4, 7 & 9 and a temperature of 25°C or 50°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.

Additional information

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:

 

The half-life of the test chemical was determined at different pH range. The study was performed at a temperature of 25°C and pH of 4, 7 and 9, respectively. As the test chemical has no groups that are susceptible to hydrolysis in the pH range 4 to 9, therefore, it is considered stable to hydrolysis in both surface and groundwater, respectively. The half-life value of test chemical was determined to be > 1 yrat pH 4, 7 and 9, respectively at a temperature of25⁰C. Thus based on this, test chemical is considered to be not hydrolysable.

 

In an another study, the half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. As the hydrolysis of test chemical did not reach > 10% in any of the pH systems, the preliminary study was terminated. Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of 50⁰C for 5 days. Based on this, it is concluded that the test substance is not hydrolysable.

 

For the test chemical, the half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 25°C. Although half-life value of test chemical was not known, but chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively & at a temperature of 25⁰C. Thus based on this, test chemical is considered to be not hydrolysable.

 

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 1 yr, at pH range 4, 7 & 9 and a temperature of 25°C or 50°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.