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Solubility in organic solvents / fat solubility

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Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
05.02.2013 - 13.02.2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Justification for type of information:
Experimental test result performed using standard test guidelines
Qualifier:
according to
Guideline:
other: Gravimetric method
Principles of method if other than guideline:
Weight of the chemical substance (fat) to dissolve in Organic Solvent to form a homogeneous solution of the solute in the solvent
GLP compliance:
no
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2-amino-4-nitrophenol
- Molecular Formula: C6H6N2O3
- Molecular Weight: 154.125 g/mol
- SMILES Notation: C1=CC(=C(C=C1[N+](=O)[O-])N)O
- InChI: 1S/C6H6N2O3/c7-5-3-4(8(10)11)1-2-6(5)9/h1-3,9H,7H2
- Substance type: Organic
- Physical state: solid
Key result
Medium:
methanol
Solubility:
3 900 mg/L
Temp.:
25 °C
Remarks on result:
other: Soluble
Conclusions:
The experimental value of solubility of 2-amino-4-nitrophenol in methanol at 25 degC was determine to be 3900 mg/L indicating that this substance is soluble in methanol.
Executive summary:

The experimental value of solubility of 2-amino-4-nitrophenol in methanol at 25 degC was determine to be 3900 mg/L indicating that this substance is soluble in methanol.

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
05.02.2013 - 13.02.2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Justification for type of information:
Experimental test result performed using standard test guidelines
Qualifier:
according to
Guideline:
other: Gravimetric method
Principles of method if other than guideline:
Weight of the chemical substance (fat) to dissolve in Organic Solvent to form a homogeneous solution of the solute in the solvent
GLP compliance:
no
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2-amino-4-nitrophenol
- Molecular Formula: C6H6N2O3
- Molecular Weight: 154.125 g/mol
- SMILES Notation: C1=CC(=C(C=C1[N+](=O)[O-])N)O
- InChI: 1S/C6H6N2O3/c7-5-3-4(8(10)11)1-2-6(5)9/h1-3,9H,7H2
- Substance type: Organic
- Physical state: solid
Key result
Medium:
other: Petroleum ether
Solubility:
110 mg/L
Temp.:
25 °C
Remarks on result:
other: moderately soluble
Conclusions:
The experimental value of solubility of 2-amino-4-nitrophenol in Petroleum ether at 25 degC was determine to be 110 mg/L indicating that this substance is moderately soluble in petroleum ether.
Executive summary:

The experimental value of solubility of 2-amino-4-nitrophenol in Petroleum ether at 25 degC was determine to be 110 mg/L indicating that this substance is moderately soluble in petroleum ether.

Description of key information

Gravimetric method was used to determine the solubility of the substance in organic solvent. The experimental value of solubility of 2-amino-4-nitrophenol in methanol at 25 degC was found to be 3900 mg/L indicating that the substance is soluble in methanol.Using the Soxhlet/Solvent extraction method the solubility of the substance in Petroleum ether is observed to be 110 mg/L at 25 °C, indicating that the substance is moderately soluble in petroleum ether. The solubility value of 2-amino-4-nitrophenol in methanol at 20 degC is equivalent to a value of 3120 mg/L.

Key value for chemical safety assessment

Solubility in organic solvents at 20°C:
3 120 mg/L

Additional information

Gravimetric method was used to determine the solubility of the substance in organic solvent. The experimental value of solubility of 2-amino-4-nitrophenol in methanol at 25 degC was found to be 3900 mg/L indicating that the substance is soluble in methanol.Using the Soxhlet/Solvent extraction method the solubility of the substance in Petroleum ether is observed to be 110 mg/L at 25 °C, indicating that the substance is moderately soluble in petroleum ether. The solubility value of 2-amino-4-nitrophenol in methanol at 20 degC is equivalent to a value of 3120 mg/L.