Registration Dossier
Registration Dossier
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EC number: 203-678-8 | CAS number: 109-53-5
Endpoint summary
Administrative data
Description of key information
IBVE was a skin irritant in rabbits after 2 or 24 hours of occlusive treatment.
Undiluted IBVE was only slightly irritant to the rabbit eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation
Three different experiments on this endpoint were presented by BASF AG (1981).
Two White Vienna rabbits receiced 0.5 mL undiluted test substance on the shaved skin. The exposure duration was 2 h under occlusive conditions (then washing off). The skin reactions were examined 24 & 48 h and 8 days post treatment. Score of erythema and edema were 2-3 24 and 48 h after application, the effects were not reversible; superficial necroses developed within 8 days following application.
In a 2nd trial using similar experimental design score of erythema and edema were 2 in two rabbits 24 and 48 h after application of 0.5 mL undiluted test substance and occlusive exposure for 2 h; at day 8 slight effects were found as well as desquamation (no later scoring).
In a 3rd experiment 6 White Vienna rabbits were exposed for 24 h under occlusive conditions to 0.5 mL of the undiluted test substance and scoring was performed immediately after the end of the exposure period and 1, 2, and 7 days after removal. Well defined to moderate erythema and edema were noted in all animals at the intact skin test sites. These skin reactions were seen at all examinations on days 0, 1, 2, and 8 after patch removal. Desquamation was noted and confirmed by pathology in all 6 rabbits at treated intact skin sites on day 7 after patch removal.
Eye irritation
Two Vienna White rabbits received instillation of one drop (appr. 50 mm³) of the undiluted test substance into the conjunctival sac. The other eye was treated with physiological saline for control. Scoring was performed 10 minutes, 1, 3, 24, 48, 72 hours and 4, 7 and 8 days after instillation. The reddening, edema or corneal opacity reached max. score 1 in both rabbits and was completely reversible in one rabbit after 24 h and in the other after 48 h. Conclusion: Undiluted test substance was only slightly irritant to the rabbit eye (BASF 1974).
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
Isobutyl vinyl ether is irritating to the skin. Therefore, classification with H315 (Cat. 2) is warranted according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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