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EC number: 203-678-8
CAS number: 109-53-5
Further details on repeated dose toxicity are presented in Section 7.5.3.
effect of treatment on weights or histopathology of male and female
In a GLP Guideline study according to OECD TG422 10 male and 10
female Wistar rats per test group were exposed to a vapor of
isobutylvinylether (whole body, 6h/d, 5d/week) at dose levels of 0, 50,
500 or 2000 ppm (0, 208, 2080 and 8300 mg/m³). The males were treated
for approx. 13 weeks (10 weeks premating, 3 weeks mating and post
mating) and females during premating (10 weeks), mating and gestation
through day 4 after delivery (approx. 15 weeks). The main target organ
was the upper respiratory tract (see also Sextion 7.5.3) at >=500 ppm.
Furthermore, dose dependent changes in some blood parameters were seen
in female animals at >=500 ppm. High serum triglyceride and cholesterol
levels were noted in high-dose parental females; the effect was less
pronounced in non-pregnant females and absent in males. Increased liver
and kidney weight changes were noted in high-dose males and intermediate
and high-dose non-pregnant females. No effects were found at any
concentration on mating and gestation index or histopathological lesions
of the reproductive organs, however, the live born index was
significantly reduced at the high dose level (increased resorptions and
reduced implantation sites reported). No other effects were seen in the
Conclusion: Reproductive toxicity (reduced live birth index
in F1) was found at 2000 ppm (8300 mg/m³) in the presence of maternal
toxicity like clinical signs and reduced body weight. The NOAEC for
reproductive toxicity is 500 ppm (2080 mg/m³). The LOAEC for toxic
effects in the nasal cavity and adaptive effects in liver and kidney of
P ratswas 500 ppm, the NOAEC was 50 ppm (208 mg/m³).
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