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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restrictions. Restriction: purity of test substance not stated; no data on clinical signs; no necropsy; only males.

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data: List VI
Author:
Smyth HF, Carpenter CP, Weil CS, Pozzani U, Striegel JA
Year:
1962
Bibliographic source:
Am Ind Hyg Assoc J 23: 95-107

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
no
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Isobutyl vinyl ether
EC Number:
203-678-8
EC Name:
Isobutyl vinyl ether
Cas Number:
109-53-5
Molecular formula:
C6H12O
IUPAC Name:
1-(ethenyloxy)-2-methylpropane
Details on test material:
isobutyl vinyl ether (IBVE), no further data

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals or test system and environmental conditions:
Male albino New Zealand rabbits weighing 2.5 to 3.5 kg were used.

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Groups of 4 animals were used. Dosages up to 20 mL/kg bw were placed on the shaved rabbit skin under occlusive dressing. The animals were immobilized during the 24 hour contact period.
Duration of exposure:
24 h
Doses:
up to 20 mL/kg bw (corresponding to 15400 mg/kg bw)
No. of animals per sex per dose:
4
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
- no data about clinical signs & body weight
Statistics:
LD50-values were estimated by the method of Thompson using the tables of Weil, based on mortalities noted during the 14-day observation period.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
15 400 mg/kg bw
Remarks on result:
other: corresponding to 20 mL/kg bw

Any other information on results incl. tables

No further data available.

Applicant's summary and conclusion

Conclusions:
In male New Zealand White rabbits the dermal LD50 was 20 mL/kg bw corresponding to 15400 mg/kg bw. The recommended limit dose according to OECD TG402 is 2000 mg/kg bw.