Isobutyl vinyl ether

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions. Restriction: purity of test substance not stated; no data on clinical signs; no necropsy; only males.

Data source

Reference

Reference Type:

publication

Title:

Range-finding toxicity data: List VI

Author:

Smyth HF, Carpenter CP, Weil CS, Pozzani U, Striegel JA

Year:

1962

Bibliographic source:

Am Ind Hyg Assoc J 23: 95-107

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

no

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Isobutyl vinyl ether

EC Number:

203-678-8

EC Name:

Isobutyl vinyl ether

Cas Number:

109-53-5

Molecular formula:

C6H12O

IUPAC Name:

1-(ethenyloxy)-2-methylpropane

Details on test material:

isobutyl vinyl ether (IBVE), no further data

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male

Details on test animals or test system and environmental conditions:

Male albino New Zealand rabbits weighing 2.5 to 3.5 kg were used.

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

Groups of 4 animals were used. Dosages up to 20 mL/kg bw were placed on the shaved rabbit skin under occlusive dressing. The animals were immobilized during the 24 hour contact period.

Duration of exposure:

24 h

Doses:

up to 20 mL/kg bw (corresponding to 15400 mg/kg bw)

No. of animals per sex per dose:

4

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
- no data about clinical signs & body weight

Statistics:

LD50-values were estimated by the method of Thompson using the tables of Weil, based on mortalities noted during the 14-day observation period.

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

15 400 mg/kg bw

Remarks on result:

other: corresponding to 20 mL/kg bw

Any other information on results incl. tables

No further data available.

Applicant's summary and conclusion

Conclusions:

In male New Zealand White rabbits the dermal LD50 was 20 mL/kg bw corresponding to 15400 mg/kg bw. The recommended limit dose according to OECD TG402 is 2000 mg/kg bw.