Registration Dossier

Administrative data

Description of key information

No study available.

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

No carcinogenicity study available for IBVE.

Methyl vinyl ether (MVE), ethyl vinyl ether (EVE, CAS 109-92-2), isobutyl vinyl ether (IBVE, CAS 109-53-5) and hydroxybutylvinylether (HBVE, CAS 17832 -28 -9) were not mutagenic in the Ames test or in mammalian cell systems (EVE, IBVE, HBVE) both in the absence and presence of metabolic activation. EVE, IBVE and HBVE did not induce chromosomal aberrations in Chinese Hamster cells. In vivo, MVE did not induce micronuclei in bone marrow of mice. The members of this category appear to have no potential to induce gene mutations or chromosomal aberrations.

IBVE is practically exclusively used as intermediate in the manufacture of vinyl ether polymers and co-polymers.

Worker exposure is controlled by the use of closed systems, industrial hygiene controls, and personal protective equipment. Potentially existing residual IBVE is expected to evaporate during the process of heat-treatment (OECD SIDS 2006). Therefore, no exposure of the general population is expected. The conduct of carcinogenicity testing is not warranted.

Justification for classification or non-classification

Classification for carcinogenicity is not warranted according to the criteria of EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.