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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Principles of method if other than guideline:
LD50 in mice after i.p. injection
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Isobutyl vinyl ether
EC Number:
203-678-8
EC Name:
Isobutyl vinyl ether
Cas Number:
109-53-5
Molecular formula:
C6H12O
IUPAC Name:
1-(ethenyloxy)-2-methylpropane
Details on test material:
no details

Test animals

Species:
mouse
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
CMC (carboxymethyl cellulose)
Details on exposure:
aqueous emulsion with CNC
Doses:
200, 1600, 2000, 2500, 3200, and 6400 µl/kg bw.
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
Observation: Observation period: 7 days. Clinical signs of toxicity, mortalities within 7 days. Terminal necropsy.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 150 mg/kg bw
Remarks on result:
other: for males and females combined

Any other information on results incl. tables

Mice died within 2 days. Mortality in males and females very similar. No mortality at <=2000 µl/kg bw.

Clinical signs: dyspnoea, convulsions, staggered gait, apathy, prone position.

No clinical effects after 7 days.

Necropsy: no effects.

Applicant's summary and conclusion

Conclusions:
LD50 in male & female mice after i.p. injection was 2150 mg/kg bw.