Registration Dossier

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study meets scientific standards

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2004
Report Date:
2004

Materials and methods

Type of study / information:
occupational exposure measurements
Endpoint addressed:
not applicable
Principles of method if other than guideline:
occupational exposure measurements
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no details available

Method

Ethical approval:
not specified
Details on study design:
no details available
Exposure assessment:
measured
Details on exposure:
no details available

Results and discussion

Results:
Values found for IBVE were on a reduced level due to the lower vapor pressure. 59 analytical values with a range of < 0.004 mg/m³ (0.001 ppm) to 5.0 mg/m³ (1.2 ppm) are available for the years 2000 - 2004. Mean value, 90 % and 95 % percentiles were at 0.26 mg/m³ (0.062 ppm), 0.96 mg/m³ (0.23 ppm), and 1.6 mg/m³ (0.39 ppm), respectively.
Similar to EVE, the higher concentrations were found during barreling. In the processing plants, highest concentrations were measured to be 0.1 and 1.1 mg/m³, respectively.

Applicant's summary and conclusion

Conclusions:
Occupational exposure measurements were documented for the years 2000 - 2004. Mean value, 90 % and 95 % percentiles were at 0.26 mg/m³ (0.062 ppm), 0.96 mg/m³ (0.23 ppm), and 1.6 mg/m³ (0.39 ppm), respectively.