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Registration Dossier
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EC number: 203-678-8 | CAS number: 109-53-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets scientific standards
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
- Type of study / information:
- occupational exposure measurements
- Endpoint addressed:
- not applicable
- Principles of method if other than guideline:
- occupational exposure measurements
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Isobutyl vinyl ether
- EC Number:
- 203-678-8
- EC Name:
- Isobutyl vinyl ether
- Cas Number:
- 109-53-5
- Molecular formula:
- C6H12O
- IUPAC Name:
- 1-(ethenyloxy)-2-methylpropane
- Details on test material:
- no details available
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- no details available
- Exposure assessment:
- measured
- Details on exposure:
- no details available
Results and discussion
- Results:
- Values found for IBVE were on a reduced level due to the lower vapor pressure. 59 analytical values with a range of < 0.004 mg/m³ (0.001 ppm) to 5.0 mg/m³ (1.2 ppm) are available for the years 2000 - 2004. Mean value, 90 % and 95 % percentiles were at 0.26 mg/m³ (0.062 ppm), 0.96 mg/m³ (0.23 ppm), and 1.6 mg/m³ (0.39 ppm), respectively.
Similar to EVE, the higher concentrations were found during barreling. In the processing plants, highest concentrations were measured to be 0.1 and 1.1 mg/m³, respectively.
Applicant's summary and conclusion
- Conclusions:
- Occupational exposure measurements were documented for the years 2000 - 2004. Mean value, 90 % and 95 % percentiles were at 0.26 mg/m³ (0.062 ppm), 0.96 mg/m³ (0.23 ppm), and 1.6 mg/m³ (0.39 ppm), respectively.
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