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EC number: 203-678-8
CAS number: 109-53-5
Eye irritation in rabbits after instillation of 0.05 ml undiluted
Rabbit 1 (male) // Rabbit 2 (female)
Scoring according to OECD TG405
Time after application
Opacity of the cornea
smeary overlay in rabbit1
smeary overlay in rabbit 1&2
smeary overlay in rabbit2
Comparable to Guideline study with acceptable restrictions (partly
limited documentation, only 0.05 ml applied).
Two Vienna White rabbits received instillation of one drop (appr. 50
mm³) of the undiluted test substance into the conjunctival sac. The
other eye was treated with physiological saline for control. Scoring was
performed 10 minutes, 1, 3, 24, 48, 72 hours and 4, 7 and 8 days after
instillation. The reddening, edema or corneal opacity reached max. score
1 in both rabbits and was completely reversible in one rabbit after 24 h
and in the other after 48 h.
Conclusion: Undiluted test substance was only slightly irritant to the
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