Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Adopted according to OECD SIDS (public available peer reviewed source). The original source is not available and has not been reviewed.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
1,4-Dichlorobut-2-ene- CAS No: 764-41-0
Author:
OECD SIDS
Year:
2006
Bibliographic source:
SIDS Initial Assessment Report for 22th SIAM, UNEP Publications
Reference Type:
study report
Title:
Unnamed
Year:
1956

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method: other: no data
GLP compliance:
no
Remarks:
was not mandatory at the time of the study

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Refined material A 9948 containing 20% cis-1,4-dichlorobut-2-ene, 45% trans-1,4-dichlorobut-2-ene and 35% 3,4-dichlorobut-1-ene.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Duration of treatment / exposure:
6 days
Frequency of treatment:
once daily
Doses / concentrations
Remarks:
Doses / Concentrations:
100 mg/kg bw/d
Basis:

Control animals:
not specified

Results and discussion

Results of examinations

Details on results:
CLINICAL SIGNS AND MORTALITY
5/6 animals died after 6 doses. Clinical signs: discomfort, diarrhoea after the third treatment, steady decline in body weight during the whole observation period.

GROSS PATHOLOGY
On pathological examination the animals which had died were found to have congested lungs and acute necrosis of the stomach, liver and spleen. The one rat which had survived the 6 treatments showed an ulceration of the stomach.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion