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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Adopted according to OECD SIDS (public available peer reviewed source). The original source is available and has been reviewed.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1959
Report Date:
1959
Reference Type:
secondary source
Title:
1,4-Dichlorobut-2-ene- CAS No: 764-41-0
Author:
OECD SIDS
Year:
2006
Bibliographic source:
SIDS Initial Assessment Report for 22th SIAM, UNEP Publications

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The forearms of volunteers were treated for 30 min to 1 hour with undiluted test substance.
GLP compliance:
no
Remarks:
GLP was not mandatory at the time of the study

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 1,4-dichlorobut-2-ene
- Analytical purity: no data

Test animals

Species:
human

Test system

Amount / concentration applied:
undiluted
Duration of treatment / exposure:
1 hour(s)

Results and discussion

In vivo

Results
Irritation parameter:
other: no data
Irritant / corrosive response data:
Considerable effects as marked erythema, swelling and blistering were observed. In some cases new severe inflammations were observed at the application site  after some time of recovery.

Applicant's summary and conclusion

Interpretation of results:
highly irritating
Remarks:
Migrated information