Registration Dossier

Administrative data

Endpoint:
nephrotoxicity
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Adopted according to OECD SIDS (public available peer reviewed source). The original source is available and has been reviewed.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Effect of dichlorobutenes on the function and structure of the kidneys.
Author:
Petrosyan FR, Gizhlaryan MS, Khechumov SA, Ervanyan AK, Darbinyan NA, Kavkasyan GV
Year:
1983
Bibliographic source:
Zh. Eksp. Klin. Med. 23, 417-421.
Reference Type:
secondary source
Title:
1,4-Dichlorobut-2-ene - CAS No: 764-41-0
Author:
OECD SIDS
Year:
2006
Bibliographic source:
SIDS Initial Assessment Report for 22th SIAM, UNEP Publications

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No data
GLP compliance:
not specified
Type of method:
in vivo

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 1,4-dichlorobut-2-ene
- Analytical purity:no data

Test animals

Species:
rat

Results and discussion

Details on results:
Single administration of 1,4-dichlorobut-2-ene to rats caused specific nephrotoxic changes manifested by disruption of canalicular reabsorption and development of necrotic nephrosis. Urinary creatinine excretion increased, compared to the control, by 65-77% after 1,4-dichlorobenzene administration. Chlorides in the urine decreased substantially (54-73%, 1,4-dichlorobenzene). Serum creatinine, however, was unchanged. Chronic intoxication affected the filtration function of the kidney and caused dystrophic changes in canalicular epithelium and glomeruli.

Applicant's summary and conclusion