Registration Dossier
Registration Dossier
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EC number: 931-313-9 | CAS number: -
Specific investigations: other studies
Administrative data
- Endpoint:
- nephrotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS (public available peer reviewed source). The original source is available and has been reviewed.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Effect of dichlorobutenes on the function and structure of the kidneys.
- Author:
- Petrosyan FR, Gizhlaryan MS, Khechumov SA, Ervanyan AK, Darbinyan NA, Kavkasyan GV
- Year:
- 1 983
- Bibliographic source:
- Zh. Eksp. Klin. Med. 23, 417-421.
- Reference Type:
- secondary source
- Title:
- 1,4-Dichlorobut-2-ene - CAS No: 764-41-0
- Author:
- OECD SIDS
- Year:
- 2 006
- Bibliographic source:
- SIDS Initial Assessment Report for 22th SIAM, UNEP Publications
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- 1,4-dichlorobut-2-ene
- EC Number:
- 212-121-8
- EC Name:
- 1,4-dichlorobut-2-ene
- Cas Number:
- 764-41-0
- Molecular formula:
- C4H6Cl2
- IUPAC Name:
- 1,4-dichlorobut-2-ene
- Details on test material:
- - Name of test material (as cited in study report): 1,4-dichlorobut-2-ene
- Analytical purity:no data
Constituent 1
Test animals
- Species:
- rat
Results and discussion
- Details on results:
- Single administration of 1,4-dichlorobut-2-ene to rats caused specific nephrotoxic changes manifested by disruption of canalicular reabsorption and development of necrotic nephrosis. Urinary creatinine excretion increased, compared to the control, by 65-77% after 1,4-dichlorobenzene administration. Chlorides in the urine decreased substantially (54-73%, 1,4-dichlorobenzene). Serum creatinine, however, was unchanged. Chronic intoxication affected the filtration function of the kidney and caused dystrophic changes in canalicular epithelium and glomeruli.
Applicant's summary and conclusion
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