Registration Dossier
Registration Dossier
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EC number: 931-313-9 | CAS number: -
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS (public available peer reviewed source). The original source is available and has been reviewed.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Influence of 1,4-dichlorobutene on the generative function of experimental animals
- Author:
- Bal'yan VV, Petrosyan FR, Gizhlaryan MS (1983)
- Year:
- 1 983
- Bibliographic source:
- Biol. Zh. Arm. 36, 663-667.
- Reference Type:
- secondary source
- Title:
- 1,4-Dichlorobut-2-ene- CAS No: 764-41-0
- Author:
- OECD SIDS
- Bibliographic source:
- SIDS Initial Assessment Report for 22th SIAM, UNEP Publications
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method: other: no data
- GLP compliance:
- not specified
- Type of assay:
- rodent dominant lethal assay
Test material
- Reference substance name:
- 1,4-dichlorobut-2-ene
- EC Number:
- 212-121-8
- EC Name:
- 1,4-dichlorobut-2-ene
- Cas Number:
- 764-41-0
- Molecular formula:
- C4H6Cl2
- IUPAC Name:
- 1,4-dichlorobut-2-ene
- Details on test material:
- - Name of test material (as cited in study report): 1,4-dichlorobut-2-ene
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 2.5 months
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.0018-0.0083 mg/L
Basis:
- No. of animals per sex per dose:
- No data
- Control animals:
- yes
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- positive
- Toxicity:
- yes
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- Inhalation of 0.0018-0.0083 mg/L 1,4-dichlorobut-2-ene for 2.5 months decreased DNA and RNA in rat spermatogenesis; 1st and 2nd order spermatocytes, spermatids, and spermatozoids. The test substance caused severe dystrophy, necrobiosis, and necrosis in the cells of spermatogenic epithelium. Endothelium of the associated blood vessels proliferated and the walls were swollen. Increased preimplantation mortality of embryos sired by the treated males with untreated females.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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