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Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
toxicity to reproduction
Remarks:
other: Embryotoxicity
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Adopted according to OECD SIDS (public available peer reviewed source). The original source is available and has been reviewed.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Embryotoxic effect of 1,4-dichloro-2-butene in inhalation administration
Author:
Bal'yan VV, Petrosyan FR, Gizhlaryan MS
Year:
1983
Bibliographic source:
Zh. Eksp. Klin. Med. 23, 118-121.
Reference Type:
secondary source
Title:
1,4-Dichlorobut-2-ene - CAS No: 764-41-0
Author:
OECD SIDS
Year:
2006
Bibliographic source:
SIDS Initial Assessment Report for 22th SIAM, UNEP Publications

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method: No data
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 1,4-dichlorobut-2-ene
- Analytical purity: no data

Test animals

Species:
rat
Strain:
not specified
Sex:
female

Administration / exposure

Route of administration:
inhalation
Duration of treatment / exposure:
Exposure period: during pregnancy
Duration of test: no data
Frequency of treatment:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
0.0016, 0.0092, 0.0339 mg/L
Basis:

Control animals:
yes

Results and discussion

Results: P0 (first parental generation)

Details on results (P0)

Microscopic study of the placenta showed blood filling of the vessels, dystrophic and necrobiotic changes in the epithelial cells of the chorion, infiltration of the lymphocytes and hystiocytes, etc. In general pregnant rats were more sensitive that the non pregnant ones. General toxicity signs from 1,4-dichlorobut-2-ene included charges in the central nervous system, a decrease in the oxygen uptake, and increase in the number of erythrocytes, leukocytes, and amount of haemoglobin in the peripheral blood.

Results: F1 generation

Details on results (F1)

At 9.2 mg/m³, the embryotoxic effects of 1,4-dichlorobut-2-ene were mild. Thus, the embryotoxic effects of 1,4-dichloro-2-ene were via placenta and uterus, although its direct action on the foetus is not ruled out.

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion