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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment: method not according to today's standard. However, according to OECD SIDS a reliability of 1 was given.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1959
Report Date:
1959
Reference Type:
secondary source
Title:
1,4-Dichlorobut-2-ene- CAS No: 764-41-0
Author:
OECD SIDS
Year:
2006
Bibliographic source:
SIDS Initial Assessment Report for 22th SIAM, UNEP Publications

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
1 drop of a 1% solution in oil was instilled into conjunctival sack of one rabbit.
GLP compliance:
no
Remarks:
was not mandatory at the time of the study

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 1,4-dichlorobut-2-ene.
- Analytical purity: no data .

Test animals / tissue source

Species:
rabbit

Test system

Amount / concentration applied:
Concentration: 1 %
Number of animals or in vitro replicates:
1

Results and discussion

In vivo

Results
Irritation parameter:
other: no data
Irritant / corrosive response data:
Effects: severe erythema and swelling of mucous membranes of the eyes.

Applicant's summary and conclusion

Interpretation of results:
highly irritating
Remarks:
Migrated information