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EC number: 203-002-1 | CAS number: 102-06-7
The test substance was administered to 6 rabbits. Three rabbits received the substance on an eye and skin. The other 3 rabbits received the substance on an eye and their eyes were washed after the administration.
In the eye irritation test, a dose of 0.1g of 1,3-diphenylguanidine (Soxinol-D) was administered to one eye of each rabbit. After the administration, strong cornea opacity, conjunctival chemosis, obvious iris congestion, conjunctival redness, a low level of eye discharge and neovascular in cornea were observed. The local reaction on the conjunctivae and the iris congestion disappeared in 3 weeks and 4 weeks, respectively, but local reactions in cornea were still recognized 6 weeks after the administration.
Based on these results, 1,3-diphenylguanidine was considered to be extremely irritating to the eyes in rabbits.
When the test was repeated with a group of 3 rabbits and eyes were washed 30 seconds after administration, obvious iris congestion, conjunctival chemosis, and a low level of conjunctival redness were observed after the administration. All of these local reactions disappeared within 72 hours after the administration, and therefore, there was a washing effect.
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