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Short-term toxicity to aquatic invertebrates

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Description of key information

In a study performed by Monsanto on the acute toxicity of 1,3 -diphenylguanidine to Daphnia a 48h-LC50 was estimated at 17 mg/l.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
17 mg/L

Additional information

In a study performed by Monsanto on the acute toxicity of 1,3 -diphenylguanidine to Daphnia a 48h-LC50 was estimated at 17 mg/l.

The acute toxicity of DPG to Daphnia magna was assessed using the methods outlined by the Commitee on Methods for Toxicity Tests with Aquatic Organisms. Water quality parameters of temperature, dissolved oxygen and pH were measured at the termination of the test and were within acceptable limits. The results of the 48 hour static Daphnia magna toxicity study are summarized below.

1,3-diphenylguanidine 48-hour LC50 = 17 (14-21) mg/1. The no effect level observed for 1,3-diphenylguanidine was 5.6 mg/1 after 48 hours.

In a more recent study performed according to the proposed procedures of the German federal environment agency (Umweltbundesamt) to determine the swimming ability of water fleas (Daphnia magna) in a static, non aerated system (21°C; pH=8, 9mg/o2/l), the 24 -hour EC50 was found to be 62.4 mg/l (geometrical mean; EC0 = 22 mg/l and EC100 = 177 mg/l). The daphnia population tested in the control was not sensitive enough to the reference substance potassium dichromate, according to the guideline.