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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

Key value for chemical safety assessment

LC50 for freshwater fish:
4.2 mg/L

Additional information

In a study performed by Bayer AG in 1970 the determination of the acute toxicity of DPG to golden orfes (Leuciscus idus) gave LC0 -72h = 1mg/l and a LC100 -48h = 10 mg/l. Nevertheless, this study is considered as not reliable due to the tested period (48h) which was shorter than the recommended exposure time period.

The acute toxicity of DPG (1,3-diphenlylguanidine) toOryzias latipeswas investigated using the Japanese Industrial Standard test (JIS K 0102 -1986 -71) (static or semi-static; 25°C +/- 2°C; solubilizer not specified). A LC50 of 10 mg/l was determined after a 48-h exposure. This study is considered as invalid due to significant methodological deficiencies.

A data sheet of the Monsanto Company (1986) contains the following information:

Pimephales promelas LC50 -96h = 4.2 mg/l

Lepomis macrochirus LC50 -96h = 9.6 mg/l

Salmo sp. LC50 -96h = 11 mg/l

Lastly, in an insufficiently documented study on Cyprinus carpio (single oral administration in gelatine capsule; flow-through system; 18°C), the following effects were observed by Loeb & Kelly (1963):

Dose in mg/kg bw

Effect / Test Duration

3.2; 6.0 and 8.7 mg/kg bw

no effects within 114 h

9.5 and 17 mg/kg bw

not specified symptoms after < 120 h, recovery after < 312 h

5.6 mg/kg bw

mortality after 71 h

9.5 and 70 mg/kg bw

not specified symptoms after >= 22 h, mortality after 125 h

Nevertheless, gavage of fish cannot be considered as relevant for aquatic ecotoxicological hazard assessment.