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Ecotoxicological information

Toxicity to birds

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In accordance with column 2 of REACH Annex X, testing on long-term or reproductive toxicity to birds (required in section 9.6.1.) should be carefully considered taking into account the large mammalian dataset that is usually available at this tonnage level.

The study on birds does not need to be conducted as sufficient reliable data is available from the mammalian data set. So, any need for testing should be carefully considered taking into account the large mammalian dataset that is usually available at this tonnage level. Nevertheless, this endpoint allows considering potential secondary poisoning issues to birds following chronic exposure to 1,3-diphenylguanidine via the fish and earthworm food chains. 1,3-diphenylguanidine and its salts are not expected to bioaccumulate in fish/earthworm tissues. Moreover, 1,3-diphenylguanidine is not expected to be persistent in aquatic and terrestrial media.Considering all those elements one can safely conclude that secondary poisoning is not expected as birds will not be exposed to 1,3-diphenylguanidine via food consumption.

On the top of that, a study on 1,3 -diphenylguanidine showed no acute toxicity to 3 song bird species: Agelaius phoeniceus, Sturnus vulgaris and Passer domesticus. After a 2 -6 weeks adaptation phase, wild-caught birds received a single oral administration of the compound dissolved in propylene glycol. The LD50 for all three species was above the highest administrated dose of 100 mg/kg bw.