Registration Dossier

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Etude expérimentale des effets physiologiques de la diphénylguanidine
Author:
Valade P, Delga J et Salle J
Year:
1949
Bibliographic source:
Comptes Rendus Soc. Biol. 143, 815-817
Reference Type:
secondary source
Title:
N,N'-Diphenylguanindine
Author:
Bayer E.
Year:
1992
Bibliographic source:
BUA Report 96 (august 1992). GDCh- Advisory Committee on existing chemicals of environmental relevance.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No detail available
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No data

Test animals

Species:
dog
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Details on inhalation exposure:
For inhalation, animals (not precised) were exposed in inhalation chamber during 30 min.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
30 min
Concentrations:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no
Statistics:
no data

Results and discussion

Preliminary study:
no data
Effect levels
Sex:
not specified
Dose descriptor:
LC0
Effect level:
>= 500 mg/m³ air (nominal)
Exp. duration:
30 min
Mortality:
no data
Clinical signs:
At 500 mg/m3, after 30 min of exposition, animals showed a slightly hypnotic effect.
Body weight:
no data
Gross pathology:
no data
Other findings:
no

Applicant's summary and conclusion