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Environmental fate & pathways

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In the MITI list (1987), DPG (1,3 -diphenylguanidine) is described as a substance with at most a slight accumulation potential in biological material. The measured log Kow value comes to reinforce this assumption. Considering these results we can make the assumption that DPG is characterized by a low potential of adsorption. That is the reason why we propose to not perform a test. On the top of that, an oldest study already exists, nevertheless very little information are available on this data in order to challenge its validity. Effectively, a study on the bioaccumulation of DPG, following test regulations similar to OECD 305C (1981), exising Cyprinus carpio for 6 weeks in a flow through system (0.2 - 0.8 ml/min; 25 +/-2°C; O2 content: 6 -8 mg/l; solubilizer was not specified), permitted to estimate a BCF of <2 and <20 at exposure concentration of 0.1 and 0.01 mg/l respectively. The substance concentration in the test medium was analyzed twice a week (CITI, 1992). As a consequence, this study is used as a supporting data in order to confort the waiving proposal.

Based upon these results and on the log Kow value (=2.42), it can be assumed that DPG is characterised by a low potential of bioaccumulation in aquatic organisms.