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Environmental fate & pathways

Biodegradation in water: screening tests

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Description of key information

According to a GLP OECD (301D) study, 1,3-diphenylguanidine is readily biodegradable.

Key value for chemical safety assessment

Biodegradation in water:
readily biodegradable

Additional information

A number of reported data were available on 1,3-diphenylguanidine from 1960 to 1988. However, data assessment was difficult because the studies were poorly documented. In two studies (Chou et al., 1983 ; Kondo, 1988), DPG was for example noted as rapidly degraded in non-adapted river water but no sound biodegradation follow-up was performed. In addition, the results of Saegar et al. (1988) suggested that the test item could be readily biodegradable. That is the reason why a full GLP OECD 301D study was commissioned in 2015. This study showed that DPG is readily biodegradable and that no persistent metabolite can be expected.