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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The study was not carried out in accordance with current guidelines and the documentation of the study is insuffcient for an assessment.

Data source

Reference
Reference Type:
publication
Title:
The toxicity of chloroform as determined by single and repeated exposure of laboratory animals
Author:
Torkelson TR, Oyen F, Rowe VK
Year:
1976
Bibliographic source:
American Industrial Hygiene Association Journal 37(12), 697-705

Materials and methods

Principles of method if other than guideline:
A single dose of chloroform was applied to the skin of healthy rabbits and kept occluded for 24 hours.
GLP compliance:
no
Test type:
fixed dose procedure
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Duration of exposure:
24 hours
Doses:
4 g/kg
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 3 980 mg/kg bw

Applicant's summary and conclusion

Conclusions:
In the test, chloroform was not acutely toxic to the rabbit via the skin.
Executive summary:

Single application of either 1.0, 2.0 or 3.98 g chloroform/kg body weight for 24 hours under an impermeable plastic cuff held tightly around the clipped bellies of each of two rabbits did not result in any deaths.

The dermal LD50 value of chloroform thus can be considered to be greater than 3.98 g/kg body weight in the rabbit.