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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study provides human information on acute effects following inhalation exposure to chloroform.

Data source

Reference
Reference Type:
publication
Title:
Studien über die Absorption chlorierter Kohlenwasserstoffe aus der Luft durch Tier und Mensch
Author:
Lehmann KB and Hasegawa
Year:
1910
Bibliographic source:
Archiv für Hygiene 72, 327-342

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
acute toxicity: inhalation
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Volunteers inhaled weighed amounts of chloroform, adverse acute effects were observed for approximately one hour
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Method

Type of population:
general
Subjects:
Three adult male scientists, approximately 25 to 45 years old, 65 kg bodyweight or heavier
Ethical approval:
no
Route of exposure:
inhalation
Reason of exposure:
intentional
Exposure assessment:
estimated
Details on exposure:
Amounts of chloroform were weighed and filled into a kind of contained bath. Volunteers inhaled vapours formed from bath by inhaling over (not through bath).
Examinations:
Absorption of material and acute adverse effects were studied.
Medical treatment:
none

Results and discussion

Clinical signs:
The results of this study showed that a 3-minute exposure to 920 ppm induced vertigo and dizziness and a 30-minute exposure to 680 ppm produced moderately strong odor. A 30-minute exposure to 1400 ppm produced lightheadedness, giddiness, lassitude, and headache while exposure to 3000 ppm resulted in gagging and pounding of the heart. Twenty-minute exposure at 4300 to 5100 ppm or 15 minute exposure at 7200 ppm produced light intoxication and dizziness.
Results of examinations:
The results of this study showed that a 3-minute exposure to 920 ppm induced vertigo and dizziness whereas only a strong odor of chloroform was detected at 680 ppm for 30 minutes.

Applicant's summary and conclusion

Conclusions:
No severe adverse effects were seen in humans after acute inhalation exposure to chloroform vapours at a concentration of 680 ppm.
Executive summary:

Three human, male adult volunteers inhaled defined amounts of chloroform during fixed periods of time. The study was not carried out in accordance with currently acceptable guidelines or fully reliable analytics. A 3-minute exposure to 920 ppm induced vertigo and dizziness and a 30-minute exposure to 680 ppm produced moderately strong odour. A 30-minute exposure to 1400 ppm produced lightheadedness, giddiness, lassitude, and headache while exposure to 3000 ppm resulted in gagging and pounding of the heart. Twenty-minute exposure at 4300 to 5100 ppm or 15 minute exposure at 7200 ppm produced light intoxication and dizziness. From this it can be concluded that inhalation of chloroform vapours at a concentration of 680 ppm for 30 minutes did not cause severe adverse effects in adult men.