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EC number: 200-521-5
CAS number: 61-82-5
Table 7.3.2/1: Ocular irritation
Region of eye
Mean (24, 48 & 72 hours)
In an eye irritation study conducted
according to the OECD Guideline 405 and in compliance with GLP, 0.1 g of
the test item was instilled into the conjunctival sac of the left eye of
each of the three female New Zealand white rabbits used. The untreated
right eye served as a control. The treated eye was gently irrigated,
approximately 30 seconds following instillation of the test substance,
with 100 mL of sterile isotonic saline solution. Any conjunctival, iris
and corneal lesions were evaluated approximately 1, 24, 48 and 72 hours
after instillation. Mean indices were calculated from results obtained
for each rabbit at times 24, 48 and 72 hours.
Conjunctivae redness (grade 1) was noted in
all animals at 1 hour after exposure; completely reversible within 24
hours. No other ocular reactions were observed. Mean individual scores
at 24, 48 and 72 hours after exposure for the 3 animals were 0, 0, 0 for
cornea score; 0, 0, 0 for iris score; 0, 0, 0 for conjunctivae score and
0, 0, 0 for chemosis score.
Under the test conditions and in accordance
with Regulation EC No. 1272/2008 (CLP), the test item was considered as
non-irritant to eye. It corresponds to UN GHS No Category. No hazard
statement or signal word is required.
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