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EC number: 200-521-5
CAS number: 61-82-5
Key study, guideline FIFRA 72 -3 (equivalent OECD 203),
LC50 (96h)> 1000 mg/L
Two acute fish studies have been
performed to assess the toxicity of amitrole. Both studies showed no
lethal effects to fish with a LC50(96h) greater than 1000 mg/L.
- The first study (Collins, 1993) was performed on seawater to assess
the acute effects of Amitrole technical to the sheephead minnow (Cyprinodon
variegatus). This study was conducted according to FIFRA guideline
72 -3 (equivalent to OECD 203) in a semi-static acute test. The test
conditions were as follows:
- dilution water: natural filtered seawater, pH 7.9, salinity 32 °/oo
- test temperature: 21 -23 °C
- nominal test concentration: 130, 220, 360, 600 and 1000 mg a.i./L
- mean measured test concentrations: 130, 220, 370, 620 and 1000 mg
a.i./L, mean measured concentrations averaged 101 % of nominal
The 96-hour LC50 value was estimated to be greater than 1000 mg a.i./L,
the highest mean measured concentration tested.
- The second study (McAllister, 1985) was performed according to
the methods outlined by the Committee on Methods for toxicity tests with
aquatic organisms on rainbow trout (Salmo gairdneri).Water
quality parameters of temperature, dissolved oxygen and pH were measured
throughout the test and were within acceptable limits. Culture and
acclimation records indicated the fish were in good condition for
The study was conducted at the following nominal concentration of
Aminotriazole: 62.5, 125, 250, 500 and 1000 mg/L. Ten fish, with a mean
weight of 0.36 (± 0.10) g and a mean standard length of 30 (± 2.3) mm,
were exposed to each test concentration and control.
The results of the four day static fish toxicity study using
Aminotriazole are summarized below. The 24- and 48 -hour LC50values
were also determined
> 1000 mg/L
Also, the results indicated a 96-hour no-observed effect
concentration could be estimated at 1000 mg/L, which was based on the
lack of mortality and abnormal effects at the highest level tested.
The missing analytical analysis in the supporting study is not
considered as a blocking point as key study results were based on mean
measured concentrations (representing more than 80 % of nominal
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