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EC number: 200-521-5
CAS number: 61-82-5
In an acute oral toxicity study performed
according to the OECD Guideline 401 and in compliance with GLP, a single
dose of 2000 or 10000 mg/kg bw (in two fractions of 5000 mg/kg bw each)
of the test substance was given by oral gavage to groups of Sprague
Dawley rats (5/sex/dose). Animals were then observed for mortality,
clinical signs and body weight changes for 14 days, and were all
sacrificed for macroscopic examinations.
No death occurred at 2000 or 10000 mg/kg bw.
Signs of hypoactivity were observed at 2000 mg/kg bw within two hours
after treatment in two females only. No clinical signs were noted at
10000 mg/kg bw. The body weight gain of the animals was not affected by
treatment with the test substance. No abnormalities were observed at
Rat Oral LD50 =10000 mg/kg bw.
Under the test conditions, the oral LD50 of
the test substance is =10000 mg/kg bw in rats. Therefore it is not
classified according to the Regulation (EC) N° 1272-2008 and according
to the Globally Harmonised System of classification and labelling of
chemicals (GHS). No signal word or hazard statement is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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