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EC number: 200-521-5
CAS number: 61-82-5
Skin irritation: Not irritating (OECD 404, GLP, Rel.2, K).Eye irritation: Not irritating (OECD 405, GLP, Rel. 2, K).
A key study was identified (CIT, 2001, rel. 2). This dermal irritation
study was performed according to the OECD Guideline No. 404, and in
compliance with GLP.
A very slight erythema was noted in all animals on Day 1; it persisted
up to Day 2 in one animal and up to Day 3 in another one. No other
cutaneous reactions were observed.
The individual scores for each animal within 3 scoring times (24, 48 and
72 h) were 0.7 / 0.0 / 0.3 for erythema and 0.0 / 0.0 / 0.0 for oedema
A key study was identified (CIT, 2002, Rel. 2). This eye irritation
study was performed according to the OECD Guideline No. 405, and in
compliance with GLP.
No corneal or iridial effects were noted during the study. Conjunctivae
redness (grade 1) was noted in all animals at 1 hour after exposure;
completely reversible within 24 hours. No other ocular reactions were
Mean individual scores at 24, 48 and 72 h after exposure for the 3
animals were 0.0 / 0.0 / 0.0 for cornea score; 0.0 / 0.0 / 0.0 for iris
score; 0.0 / 0.0 / 0.0 for conjunctivae score and 0.0 / 0.0 / 0.0 for
The substance has no harmonized
classification for irritation or corrosion according to the Regulation
(EC) No. 1272/2008.
Based on the available data no additional
self-classification is proposed regarding both skin and eye
irritation according to the Annex VI of the Regulation (EC) No.
1272/2008 (CLP) and to the GHS.
No data was available regarding respiratory
irritation, however the substance not being classified for skin and eye
irritation, no classification is expected for respiratory irritation.
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