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EC number: 200-521-5
CAS number: 61-82-5
In an acute dermal toxicity study performed
according to the OECD Guideline 402 and in compliance with GLP, a single
dose of 2000 mg/kg bw of the test substance was applied to the skin of 5
male and 5 female Sprague-Dawley rats under semi-occlusive dressings for
24 hours. Animals were then observed for mortality, clinical signs and
body weight changes for 14 days, and were all sacrificed for macroscopic
No clinical signs and no deaths were
observed during the study. No cutaneous reactions were observed. A
reduced weight gain or a slight body weight loss was seen in 3/5 females
between Day 1 and Day 8 and in 2/5 females during the second week of the
observation period. The body weight gain of the other treated animals
was similar to that of historical control animals. No apparent
abnormalities were observed at necropsy in any animal.
Rat dermal LD50 >2000 mg/kg bw.
Under the test conditions, the dermal LD50 of the test substance is
higher than 2000 mg/kg bw in rats as it is the maximum dose tested and
is expected to be higher than 5000 mg/kg bw, therefore it is not
classified according to the Annex VI of the Regulation (EC) No.
1272/2008 (CLP) and to the GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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