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EC number: 200-521-5
CAS number: 61-82-5
Table 7.3.1/1 : Individual skin
Mean (24, 48 and 72 hours)
In a primary dermal irritation study
performed according to OECD Guideline 404 and in compliance with GLP, a
single dose of 500 mg of the test item in its original form was applied
under semi-occlusive dressing for 4 hours to the closely-clipped skin of
one flank of three male New Zealand White rabbits. After removal of the
dressing, cutaneous reactions were scored as outlined in the OECD
Guideline 404 at 1, 24, 48 and 72 hours.
A very slight erythema was noted in all
animals on Day 1; it persisted up to Day 2 in one animal and up to Day 3
in another one. No other cutaneous reactions were observed. Mean scores
over 24, 48 and 72 hours for each animal were 0.7, 0.0 and 0.3 for
erythema and 0.0, 0.0 and 0.0 for oedema.
Under the test conditions and in accordance
with Regulation EC No. 1272/2008 (CLP), the test item was considered as
non-irritant to skin. It corresponds to UN GHS No Category. No hazard
statement or signal word is required.
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