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EC number: 200-521-5
CAS number: 61-82-5
In an acute inhalation toxicity study,
groups of Wistar rats (10/sex/dose) were exposed to the test item
aerosol at concentrations of 5 and 10% in a (1:1) mixture of ethanol and
Lutrol in a dynamic inhalation system for 4 hours. The theoretical
concentrations were 1000 or 2000 mg/m3 air (maximum producible
concentration in air); and the corresponding analytical concentrations
were 280 or 439 mg/3 air. All animals were observed for mortality,
clinical signs and body weight changes for 14 days, and were all
sacrificed for macroscopic examinations.
No deaths occurred and the rats tolerated
the concentrations without symptoms. No toxicologically relevant or
concentration-related effects on the bodyweights were observed. No
indications of organic injury were found during necropsy.
Rat, LC50, 4 hour exposure > 439 mg/m3 air
(maximum producible analytical concentration in air)
Under the test conditions, the 4 hour, LC50
of the test substance is higher than 439 mg/m3 air in rats as it
was the maximum achievable concentration. However, no effects were
observed in this study and in the acute oral toxicity study up to 10000
mg/kg bw therefore the inhalation LC50(4h) in rats is expected to be
higher than 5000 mg/m3 air and the test substance is not classified for
acute inhalation toxicity according to the Annex VI of the Regulation
(EC) No. 1272/2008 (CLP) and to the GHS.
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