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EC number: 200-521-5
CAS number: 61-82-5
The substance has low potential for bioaccumulation, according to
Regulation (EC) No.1272/2008 (CLP) criteria for classification in
aquatic chronic toxicity hazard class (log Kow <4).
It should also be of no concern for PBT assessment.
An experimental study, conducted according to a recognized OECD/EC
method and under GLP, is available. Despite major deviation to the
guideline on maximum phases concentrations, reliability was considered
as acceptable, and the magnitude of order is sufficient for purpose,
with margin of safety regarding CLP and PBT assessment.
The substance being ionisable, determinations were conducted at
different pH. Results (as log) were -0.93, -0.77 and -0.80, respectively
at pH 4.5, 7.1 and 9.9. Considering the substance is a primary amine, it
exists mainly under its non-ionised form -NH2, which is the relevant
form for the definition of logKow, at pH at least 2 units above its pKa
of ca 4.1. Due to the deviation, results at pH 7.1 and 9.9 are regarded
as equivalent, and the lower log Kow value is chosen as key data, as
considered to be a worst-case. A lower partition coefficient, expressed
as logD, at acidic pH is consistent with the partially ionised form,
more soluble in water.
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