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Ecotoxicological information

Long-term toxicity to fish

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Description of key information

Key study, following U.S. EPA Draft Medaka Multigenerational Test Guideline, the OECD Draft Guideline Fish Two-generation Test and JMOE Annex 6.2 The Medaka (Oryzias latipes) Full Life-Cycle Test Guideline, GLP:

The study was not performed at a concentration high enough to be able to define a genuine NOEC as the maximum concentration test was 9 µg/L :

35d-NOEC (Oryzias latipes) = 9.0 µg a.i./L (based on F0 generation reproduction data and on nominal concentrations further to analytical confirmation that concentrations remained within + or - 20% of the nominals)

58d-NOEC (Oryzias latipes) = 9.0 µg a.i./L (based on F1 generation, all endpoints data and on nominal concentrations further to analytical confirmation that concentrations remained within + or - 20% of the nominals)

69d-NOEC (Oryzias latipes) = 9.0 µg a.i./L (based on F2 generation, all endpoints data and on nominal concentrations further to analytical confirmation that concentrations remained within + or - 20% of the nominals)

Key value for chemical safety assessment

Additional information