Registration Dossier
Registration Dossier
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EC number: 200-521-5 | CAS number: 61-82-5
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key study, following U.S. EPA Draft Medaka Multigenerational Test Guideline, the OECD Draft Guideline Fish Two-generation Test and JMOE Annex 6.2 The Medaka (Oryzias latipes) Full Life-Cycle Test Guideline, GLP:
The study was not performed at a concentration high enough to be able to define a genuine NOEC as the maximum concentration test was 9 µg/L :
35d-NOEC (Oryzias latipes) = 9.0 µg a.i./L (based on F0 generation reproduction data and on nominal concentrations further to analytical confirmation that concentrations remained within + or - 20% of the nominals)
58d-NOEC (Oryzias latipes) = 9.0 µg a.i./L (based on F1 generation, all endpoints data and on nominal concentrations further to analytical confirmation that concentrations remained within + or - 20% of the nominals)
69d-NOEC (Oryzias latipes) = 9.0 µg a.i./L (based on F2 generation, all endpoints data and on nominal concentrations further to analytical confirmation that concentrations remained within + or - 20% of the nominals)
Key value for chemical safety assessment
Additional information
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